Sababta ugu badan ee caadiga ahkelyaha oo daba-dheeraada waa sokorowga, ha ahaado nooca 1 ama nooca 2. Tani waa sababta oo ah cudurka macaanku wuxuu waxyeeleeyaa xididdada dhiigga yaryar, oo ay ku jiraan kuwa gudaha kelyaha. Guud ahaan, cudurrada keena dhibaatooyinka wadnaha iyo xididdada dhiigga ayaa sidoo kale ah arrimo halis u ah cudurrada kelyaha. Gabow, dhiig karka, buurnaanta, sonkorowga, sigaarka iyo kolestaroolka HDL oo hooseeya ("kolestarool wanaagsan")¹. Waxyaabaha kale ee khatarta ah waxay keeni karaan cudur kelyo daba-dheeraaday, oo ay ku jiraan kuwan soo socda:

• Pyelonephritis (caabuqa kelyaha);
• Cudurka kelyaha ee polycystic;
• Cudurada difaaca jirka, sida nidaamka lupus erythematosus;

• Kaadi-mareenka oo istaaga (sida qanjirka 'prostate' oo weyn);
• Isticmaalka dawooyinka ay kelyuhu metaboolaan, sida daawooyinka kemotherabi ee kansarka qaarkood.