Hypogammaglobulonemia waa hoos u dhac ku yimaada heerka gamma-globulins ama immunoglobulins, walxaha doorka muhiimka ah ku leh habka difaaca jirka. Cilad-xumada bayoolojigu waxay sabab u noqon kartaa qaadashada daawooyinka qaarkood ama cudurro kala duwan, kuwaas oo qaarkood u baahan baadhitaan degdeg ah. 

Hypogammaglobulinemia waxaa lagu qeexaa heerka gamma-globulin ee ka yar 6 g / l ee borotiinka plasma electrophoresis (EPP). 

Gamma globulin, oo sidoo kale loo yaqaan immunoglobulins, waa walxo ay sameeyeen unugyada dhiiga. Waxay door aad u muhiim ah ku leeyihiin difaaca jirka. Hypogammaglobumonemia waxay keentaa hoos u dhac aad u daran oo ku yimaada difaacayaasha difaaca. Waa dhif.

Baaritaanka u oggolaanaya go'aaminta gamma-globulins, iyo waxyaabo kale, waa electrophoresis ee borotiinka serum ama borotiinka plasma. Waxaa la sameeyaa haddii laga shakiyo cudurrada qaarkood ama ka dib natiijooyin aan caadi ahayn inta lagu jiro baaritaannada ugu horreeya. 

Baadhitaankan waxaa loo qoraa haddii laga shakiyo yaraanta difaaca ee humoral ee joogitaanka caabuqyada soo noqnoqda, gaar ahaan ENT iyo bronchopulmonary sphere ama ka sii daridda xaaladda guud, haddii laga shakiyo myeloma badan (calaamadaha: lafo xanuun, dhiig-yaraan, infekshannada soo noqnoqda…). 

Baadhitaankan waxa kale oo la isticmaali karaa ka dib natiijooyin aan caadi ahayn oo muujinaya korodhka ama hoos u dhaca borotiinka serum, borotiinka kaadida oo sarreeya, kalsiyumka dhiigga oo sarreeya, cillad aan caadi ahayn ee tirada unugyada dhiigga cas ama unugyada dhiigga cad.

Electrophoresis ee borotiinka serum waa baaritaanka kaas oo suurtogal ka dhigaya in la cabbiro gamma globulins. 

Tijaabada bayoolojiga ee joogtada ah (muunada dhiiga, inta badan suxulka) waxa ay ogolaataa habka tirada ee qaybaha kala duwan ee borotiinka serum (albumin, alpha1 iyo alpha2 globulins, beta1 iyo beta2 globulin, gamma globulin). 

Electrophoresis ee borotiinka serum waa baaritaan fudud kaas oo suurtogal ka dhigaya in la ogaado lagana qayb qaato la socodka cuduro badan: xanuunka caabuqa, kansarrada qaarkood, jirrooyinka jireed ama nafaqada.

Waxay u jihaysataa baaritaannada dheeriga ah ee lagama maarmaanka ah (tallaalka iyo/ama baaritaannada gaarka ah ee borotiinnada, qiimeynta dhiigga, sahaminta kelyaha ama dheefshiidka).

Helitaanka hypogammaglobulonemia waxaa laga yaabaa inay sabab u tahay qaadashada daawooyinka (daaweynta corticosteroid afka, difaaca difaaca jirka, ka hortagga suuxdinta, daaweynta kemotherabi, iwm) ama cudurro kala duwan. 

Baaritaano dheeri ah ayaa ogolanaya in la ogaado cudurka marka sababta dawada meesha laga saaro. 

Si loo ogaado cudurada kuwaas oo ah xaaladaha degdegga ah ee ogaanshaha (silsiladda iftiinka myeloma, lymphoma, myeloid leukemia chronic), saddex baaritaan ayaa la sameeyaa: raadinta burada syndrome (lymphadenopathy, hepato-splenomegaly), ogaanshaha borotiinka iyo tirada dhiigga.

Marka xaaladahan degdega ah ee ogaanshaha meesha laga saaro sababaha kale ee hypogammaglobulonemia ayaa la sheegay: nephrotic syndrome, exudative enteropathies. Sababaha keena enteropathies exudative waxay noqon karaan cudur mindhicir barar ah oo daba-dheeraada, cudurka baruurta iyo sidoo kale burooyinka dheefshiidka adag ama qaar ka mid ah hemopathies lymphoid sida lymphoma ama amyloidosis aasaasiga ah (LA, silsilad iftiin amyloidosis ee immunoglobulins).

Marar dhif ah, hypogammaglobulonemia waxaa sababi kara yaraanta difaaca jirka.

Nafaqo-xumo daran ama Cushing's syndrome ayaa sidoo kale noqon kara sababta hypogammaglobulonemia.

Baadhitaano dheeraad ah ayaa u oggolaanaya in la ogaado cudurka (scanner thoraco-abdominal-pelvic scanner, tirada dhiigga, shaqada bararka, albuminemia, proteinuria 24-saac ah, go'aaminta miisaanka immunoglobulins iyo difaaca jirka)

Daaweyntu waxay kuxirantahay sababta keentay. 

Waxaa lagu dejin karaa daaweyn ka hortag ah dadka qaba hypogammaglobulinemia: tallaalka anti-pneumococcal iyo tallaalada kale, ka hortagga antibiyootiga, beddelka polyvalent immunoglobulins.