Caddaynta isbeddelka arrinta cad ee ku xeeran neurons -ka, leukoencephalopathy multifocal horusocodku waa cudur neerfaha oo isla mar saameeya dhowr gobol oo maskaxda ah oo si tartiib -tartiib ah u socda. Sababihiisu waa badan yihiin. 

Neurons (unugyada neerfaha ee maskaxda) waxaa fidiya xargaha neerfaha, oo loo yaqaan axons, kaas oo ku xirmi doona kuwa kale ee maskaxda iyada oo loo marayo isdabajooga (dhammaadka axon). Xadhkaha neerfayaashaan waxaa ku wareegsan gal (myelin) kaas oo ka soocaya midba midka kale waana qayb ka mid ah arrinta cad ee maskaxda.

Leukoencephalopathy multifocal horusocod ah (PML) waxay ka marag kacaysaa in wax laga beddelo meelo badan oo ka mid ah maskaxda galkan oo ku wareegsan axons -ka, taasoo dhalisa wareegyo gaagaaban. Wareegyadan gaagaaban waxay asal u yihiin cilladaha maskaxda ee la xiriira abaabulka muruqyada, waxqabadka maskaxda (fikirka ama garashada) iyo fiilooyinka dareemayaasha ee dareenka. Sidaa darteed dhacdada curyaannimo, khalkhalka fekerka iyo dareenka.

Xanuunkan neerfayaasha ee xumaada ayaa inta badan horumarsan, oo u soo ifbaxaya si tartiib tartiib ah ama si tartiib tartiib ah oo isku mar u saameeya dhowr meelood oo maskaxda ah (multifocal). Sababihiisu aad bay u badan yihiin astaamihiisuna waxay ku xiran yihiin goobaha ay saameeyeen.

Sababaha horumarka leukoencephalopathy multifocal (PML) waa kuwo badan oo kala duwan dabeecadda:

Hiddo ama hidde

Mararka qaarkood bilawga goor hore sida cudurrada qaarkood ama cudurada sida cudurka Cadasil oo ku xidhan mutation hidde, Carruurnimada Ataxia syndrome asal ahaan godadka ku jira arrinta cad ee maskaxda burburinta myelin, sclerosis multiple (MS) oo ku dhacda asaaska dhaxalka ah oo waliba mararka qaarkood sababa godadka (qaabka godka MS), ama cudurrada maskaxda ku dhaca sida X X oo jilicsan ama cudurka mitokondrial.

Asalka xididada

Waa waallida xididdada dhiigga oo ay sababto waxyeellada maraakiibta yaryar ee maskaxda (microangiopathy), oo la xiriira da'da, dhiig -karka ama duqoobay oo aan dheelitirnayn ama sonkorow.

Asal ahaan sun ah 

Adigoo qaadanaya daawooyin gaar ah sida methotrexate oo loo isticmaalo daaweynta kansarrada qaarkood ama cudurrada difaaca jirka (rheumatoid arthritis ama RA, iwm.), Sumowga nitric oxide (kulaylinta gaas cillad leh) ama neefsashada uumiga hirowiinta (isticmaalka qabatinka). Daaweynta shucaaca ayaa sidoo kale beddeli karta arrinta cad ee maskaxda ku jirta.

Asal ahaan xumaaday

Waxay ku xiran tahay geeddi -socodka bararka ee saameeya habdhiska neerfaha sida MS, leucoaraiosis, ama cudurka Alzheimers, mararka qaarkood asal ahaan la iska dhaxlo laakiin had iyo jeer ma aha, oo leh cudurka dambe ee uruurinta kaydadka oo carqaladeyn doona gudbinta neuronal (kaydka amyloid iyo xumaanshaha neurofibrillary ee la xiriirta joogitaanka borotiinka maskaxda, beta-amyloid peptide iyo protein tau).

Asalka faafa

Marar dhif ah cudurrada fayraska sida papillomavirus (fayraska JC) ama AIDS (2 ilaa 4% HIV + dadka).

Astaamaha horumarka leukoencephalopathy multifocal (PML) way kala duwan yihiin iyadoo ku xiran aagagga ay dhibaatadu saameysey iyo sababta geedi socodkan xumaaday ee maskaxda:

• dareemidda tabar -dari, hadalka oo adkaada ama fekerka bilowga cudurka;
• gariir ula kac ah (cerebellar syndrome) iyo khalkhal ku dhaca cilladda X ama cudurka mitochondrial, khalkhalka isuduwidda ikhtiyaariga ah, astaamaha muujiya horaantii hore ee cudurrada hidde -sidayaasha ama hidde -wadayaasha oo si tartiib tartiib ah iyo lama huraan u socda…;
• xanuunnada dhimirka inta lagu jiro hoos u dhaca asalka xididdada dhiigga, oo inta badan ku dhaca dadka waayeelka ah oo leh cillado niyadda, cillado garashada (temporo-spatial disorientation, disorders memory), mararka qaarkood dhalanteed iyo wareer;
• Dareen -darrada daciifka ah iyo xirfadaha mootada ee xumaanshaha asalka sunta ah;
• hoos u dhaca garashada ee hoos u dhaca maskaxda sida cudurka Alzheimers oo leh xusuusta daciifka ah, jihaynta, feejignaanta, xallinta dhibaatooyinka, qorsheynta iyo abaabulka, fikirka;
• halista shilalka maskaxda (istaroogga) ayaa ku kordhay leukoencephalopathy badan -socodka;
• dhanjafka iyo suuxdinta.

Calaamadaha kiliinikada ayaa durbaba soo jeedinaya cudurkan, laakiin waxay noqon doontaa sawirka maskaxda sida Magnetic Resonance Imaging (MRI) oo suuragelin doonta in la helo nabaro soo jeedinaya arrinta cad ee maskaxda.

Ogaanshaha fayraska JC ee daloolka lumbar ayaa mararka qaarkood la tilmaamaa haddii laga shakiyo horusocod badan oo leukoencephalopathy ee asalka fayraska.

Baadhitaanka AIDS -ka badiyaa waa la sameeyay haddii kalese waa in la baaraa.

Daaweynta leukoencephalopathy badan -socodka badan leh ayaa ah sababta:

• raadinta sababaha sunta ah (daroogada, hirowiin, iwm.) oo dabargo; 
• xaqiijinta ogaanshaha cilladda maskaxda ee cudurka Alzheimers, MS, leukoaraiosis, waallida asalka xididdada.

Dhaawacyada arrinta cad ayaa sii ahaan doona kuwo aan dib loo noqon karin oo taageero nafsaani -bulsho iyo kicinta garashada ayaa hoos u dhigi doonta horumarka cudurkan oo mararka qaarkood soo ifbaxaya dhowr sano.