Hormoonka kicinta follicle, ama FSH, waa hoormoonka bacriminta ee ragga iyo dumarka labadaba. Tani waa sababta inta lagu jiro baaritaanka bacriminta, heerka si nidaamsan loo hubiyo.

Haweenka

HSF waxay ku dhacdaa wejiga koowaad ee wareegga ugxansidaha, oo loo yaqaan wejiga follicular. Inta lagu jiro marxaladan, oo bilaabma maalinta ugu horeysa ee caadada oo dhammaata wakhtiga ugxan, hypothalamus waxay soo saartaa neurohormone, GnRH (hormoonka sii deynta gonadotropin). Silsilad falcelinta ayaa raaci doonta:

• GnRH waxay kicisaa qanjidhada pituitary, taas oo ka jawaab celinaysa FSH;
• hoos saamaynta FSH, ku dhawaad ​​labaatan follicle ugxan-sidaha bilaabi doona inay koraan;
• xubnahaan bislaaday ayaa iyana soo daaya estrogen, mas'uul ka ah dhumucda xuubka ilmo-galeenka si loogu diyaariyo ilmo-galeenka si uu u helo ukun la bacrimiyay oo suurtogal ah;
• kooxda dhexdeeda, hal follicle, oo loo yaqaan follicle-ka ugu weyn, ayaa gaadha ugxanta. Kuwa kale waa la tirtiri doonaa;
• marka la doorto follicle-ka ugu weyn ee preovulatory, dheecaanka estrogen aad ayuu u kordhaa. Korodhkani wuxuu keenaa kor u kaca LH (hormoonka luteining) kaas oo kicin doona ugxan-sidaha: follicle-ka qaan-gaadhka ah ayaa dillaaca oo sii daaya oocyte.

Xuddunta falcelinta silsiladdan, FSH sidaas darteed waa hoormoon muhiim u ah bacriminta.

Insaanka

FSH waxay ku lug leedahay spermatogenesis iyo dheecaanka testosterone. Waxay kicisaa unugyada Sertoli oo soo saara shahwada xiniinyaha.

Haweenka, qiyaasta FSH waxaa lagu qori karaa xaalado kala duwan:

• haddii ay dhacdo amenorrhea aasaasiga ah iyo / ama qaan-gaarnimada dambe: qiyaas isku dhafan oo FSH ah iyo LH ayaa la sameeyaa si loo kala saaro inta u dhaxaysa asaasiga (asalka ugxansidaha) ama sare (asalka sare: hypothalamus ama pituitary) hypogonadism;
• haddii ay dhacdo amenorrhea sare;
• Haddii ay dhacdo dhibaato dhalmo la'aan, qiimeyn hormoon ayaa lagu sameeyaa qiyaasta hormoonnada jinsiga ee kala duwan: follicle stimulating hormone (FSH), estradiol, luteining hormone (LH), hormoonka antimuleric (AMH) iyo xaaladaha qaarkood prolactin, TSH (thyroid). ), testosterone. Tijaabada FSH waxay caawisaa qiimaynta kaydka ugxan-sidaha iyo tayada ugxan-sidaha. Waxay ogolaataa in la ogaado haddii cilladda ugxan-sidaha ama amenorrhea ay sabab u tahay gabowga ugxan-sidaha ama ku lug lahaanshaha qanjirka pituitary.
• menopause, go'aaminta FSH laguma talinayo si loo xaqiijiyo bilawga menopause iyo menopause (HAS, 2005) (1).

Insaanka

Qiimaynta FSH waxaa la samayn karaa iyada oo qayb ka ah qiimaynta bacriminta, iyada oo ay jirto xaalad aan caadi ahayn ee shahwada (azoospermia ama oligospermia daran), si loo ogaado hypogonadism.

Cabbirrada hormoonnada waxaa laga soo qaadaa baarista dhiigga, laguma sameeyo calool madhan.

• Haweenka, go'aaminta FSH, LH iyo estradiol waxaa lagu fuliyaa 2nd, 3rd ama 4th maalinta wareegga shaybaar tixraaceed.
• Bini'aadamka, qiyaasta FSH waxaa la samayn karaa wakhti kasta.

Dumarka:

• korodhka muuqda ee FSH iyo LH waxay muujinayaan fashilka asaasiga ah ee ugxansidaha;
• hoos u dhac weyn oo ku yimid LH iyo FSH inta badan waxay ka tarjumaysaa dhaawaca qanjidhada pituitary, asaasiga ah ama sare (buro, necrosis pituitary, hypophysektomi, iwm.);
• Haddii FSH ay sarreyso iyo/ama estradiol hooseeyo, hoos u dhaca kaydka ugxan-sidaha ayaa la tuhunsan yahay ("Menopause hore").

Dadka dhexdiisa:

• heerka sare ee FSH wuxuu muujinayaa dhaawaca tuubada xiniinyaha ama seminiferous;
• haddii ay hooseyso, ku lug lahaanshaha "sare" (hypathalamus, pituitary) ayaa la tuhunsan yahay. MRI iyo baaritaan dhiig oo dhameystiran ayaa la sameyn doonaa si loo eego ku filnaanta pituitary.

Dumarka:

• Haddii ay dhacdo in ugxan-la'aan ama ku lug lahaanshaha qanjirka pituitary, daaweynta kicinta ugxan-sidaha ayaa la bixin doonaa. Ujeeddadeedu waa soo saarista hal ama laba oocytes oo baaluq ah. Hab-maamuusyo kala duwan ayaa jira, dariiqa afka ama irbado;
• haddii ay dhacdo menopause degdeg ah, tabarucaad oocyte ah ayaa la bixin karaa.

Dadka dhexdiisa:

• Haddii ay dhacdo hypogonatotropic hypogonadism (isbeddelka dhidibka hypotalamic-pituitary) oo leh azoospermia daran ama oligospermia, daaweynta dib u soo celinta spermatogenesis ayaa loo qori doonaa. Laba nooc oo unugyo ah ayaa loo isticmaali karaa: gonadotropins oo leh firfircoonida FSH iyo gonadotropins leh waxqabadka LH. Hab-maamuusyada, kuwaas oo ku kala duwan si waafaqsan bukaanka, waxay socdaan 3 ilaa 4 bilood, ama xitaa ka badan xaaladaha qaarkood.
• haddii ay dhacdo isbedel shahwadeed oo daran iyo azoospermia qaarkood (taas oo ay suurtogal tahay in qaliinka laga saaro shahwada epididymis ama xiniinyaha), IVF oo leh ICSI ayaa la bixin karaa. Farsamadan AMP waxay ka kooban tahay in shahwada si toos ah loogu duro cytoplasm ee oocyte qaangaadhka ah;
• ku-deeqidda shahwada ayaa laga yaabaa in la siiyo lammaanaha haddii shahwada la soo celin kari waayo.