Neuroleptic malignant syndrome waa cudur lagu garto cudur heerka neerfaha ah. Cudurkaan guud ahaan waa natiijada saameynaha soo raaca marka la qaadanayo daawooyinka sida neuroleptics ama anti-psychotics. (2)

Cilad-xumadani waxay ku xidhan tahay xaalad doqonnimo ah, taas oo ah in la yidhaahdo habka uu qof kasta u yahay, falcelintiisa iyo hab-dhaqankiisa deegaanka.

Cilmi-nafsiyeedkan wuxuu keenaa qandho sare, dhidid, xasillooni darro xagga cadaadiska dhiigga, murqaha oo adkaada iyo cillad la'aanta qalabka iswada.

Inta badan, calaamadaha ugu horreeya waxay soo baxaan laba toddobaad ka dib daaweynta neuroleptics ama anti-psychotics. Si kastaba ha ahaatee, calaamadaha la xidhiidha cudurka ayaa laga yaabaa inay soo baxaan inta lagu jiro qaadashada daawada.

Kiisaska cudurka 'neuroleptic malignant syndrome' ayaa sidoo kale la keenay safka hore ka dib daawaynta joojinta ee daawooyinka ka hortagga Parkinson. (2)

Ogaanshaha degdega ah ee xanuunka 'neuroleptic malignant syndrome' oo ay keento qaadashada neuroleptics ama anti-psychotics waxay suurtogal ka dhigtaa in la yareeyo cawaaqibka la xidhiidha.

Cudurka 'Neuroleptic malignant syndrome' wuxuu saameeyaa qiyaastii 1 ilaa 2 kiis 10 bukaan oo la marsiiyo daawaynta neuroleptic ama antipsychotic. Faafitaankani waxa uu khuseeyaa ragga iyo dumarka labadaba iyada oo wax yar ay u sarreeyaan ragga, da' kasta leh. (000)

Cudurka 'Neuroleptic malignant syndrome' wuxuu la xiriiraa astaamo caafimaad oo kala duwan sida: (1)

• pyrexia: joogitaanka qandho daran ama xaalad qandho joogto ah;
• hypertonia muruqa: codka kor u kaca ee muruqyada;
• isbeddellada xaaladaha maskaxda;
• Deregulation hemodynamic (deegulation ee wareegga dhiigga)

Dabeecad gaar ah oo loo yaqaan 'neuroleptic malignant syndrome' waa joogitaanka qallafsanaan muruqa ah oo la xidhiidha maqnaanshaha falcelis: "tuubo-lead" qallafsanaan. (1)

Astaamaha marka la eego calaamadaha muhiimka ah ayaa sidoo kale lagu arki karaa noocyadan pathology: (4)

• dhiig-kar;
• tachycardia (garaac degdeg ah);
• tachypnea (neefsasho degdeg ah);
• hyperthermia (> 40 °), oo ay sababtay jiritaanka qandho daran;
• salivation;
• acidosis (ashito dhiiga oo leh pH dhiig oo ka hooseeya heerka caadiga ah ee u dhexeeya 7.38 iyo 7.42.);
• cesho la'aan.

Isbeddellada cabbirrada noolaha ayaa sidoo kale lagu arki karaa nooca cudurka: (4)

• heerka sare ee serum phosphokinases iyo transaminases;
• rhabdomyolysis (burbur ku yimaada unugyada muruqa gudaha murqaha jeexan).

Horumarinta xanuunka 'neuroleptic malignant syndrome' ayaa ka soo baxa saameynaha la xidhiidha qaadashada daawooyinka noocyada: neuroleptics iyo anti-psychotics.

Qodobka ugu muhiimsan ee khatarta ah ee horumarinta neuroleptic malignant syndrome waa isticmaalka neuroleptics ama anti-psychotics. (4)

Intaa waxaa dheer, daal jidhka ah, nasasho la'aan, fuuq-baxa ayaa ah arrimo dheeraad ah oo ku saabsan khatarta ah inuu ku dhaco cudurka.

Bukaan-socodka qaata neuroleptics ama anti-psychotics ee qiyaaso badan, qaabka parenteral (maamulka daroogada ee marinka xididada, muruqyada, iwm.) ama korodhka degdega ah ee qiyaasta ayaa halis weyn u ah horumarinta pathology. (4)

Daawaynta xanuunkan waa mid aad u adag.

Daawooyinka xanuunka keena (neuroleptic ama antipsychotic) waa la joojiyaa waxaana lagu daaweeyaa si adag.

Daawooyinka u oggolaanaya nasashada muruqa ayaa laga yaabaa in la qoro. Intaa waxaa dheer, daaweynta dopamine-ku salaysan (daawoyinka dopaminergic) ayaa inta badan faa'iido u leh daaweynta cudurkan. (2)

Ilaa hadda, ma jiro daaweyn gaar ah oo loo yaqaan 'syndrome' oo ah mawduuca caddayn la taaban karo.

Si kastaba ha noqotee, faa'iidooyinka daaweynta benzodiazepines, wakiilada dopaminergic (bromocriptine, amantadine), dantrolenes (nasiibiyeyaasha murqaha) iyo daawaynta korantada ayaa la soo sheegay.

Kormeer taxaddar leh ayaa lagama maarmaan u ah bukaannada qaba wadnaha wadnaha-neefsashada, shaqada kelyaha, oof-wareenka iyo xinjirowga dhiigga.

Intaa waxaa dheer, gargaarka neefsashada iyo sifeynta ayaa laga yaabaa in loo qoro.

Xaaladaha intooda badan, bukaanada qaba neuroleptic malignant syndrome waxay sameeyaan soo kabasho buuxda. Si kastaba ha noqotee, calaamadaha amnesic, extrapyramidal (oo ay weheliyaan xanuunada neerfaha), cilladaha maskaxda, neuropathy peripheral neuropathy, myopathy iyo qandho ayaa laga yaabaa inay sii jiraan xaaladaha qaarkood. (4)

Maqnaanshaha daawaynta iyo ka dib joojinta daawada dhimirka ee xanuunka keena, neuroleptic malignant syndrome guud ahaan waa la daaweeyaa inta u dhaxaysa 1 iyo 2 toddobaad.

Intaa waxaa dheer, xanuunka 'syndrome' ayaa laga yaabaa inuu u dhinto.

Sababaha dhimashada marka la eego macnaha guud ee cudurkan waa xiritaanka wadnaha sambabada, oof-wareen (ku lug lahaanshaha sambabada oo lagu gartaa dib u soo noqoshada dheecaanka bronchi ee caloosha), embolism sambabada, kelyaha myoglobinuric (kelyaha oo aan shaqeynin oo leh joogitaanka dhiigga kaadida). , ama faafin xinjirowga xididdada dhiigga. (4)

Heerka dhimashada ee la xidhiidha pathology-gan waa inta u dhaxaysa 20 iyo 30%.