Xaqiiqda ah in mustaqbalka dhow oncology ay ugu dambeyntii joojin doonto inay noqoto jumlad, saynisyahannadu waxay mar kale bilaabeen inay hadlaan. Waxaa intaa dheer, daahfurka ugu dambeeyay ee cilmi-baarayaasha ka socda Jaamacadda Notre Dame (South Bend, United States) ayaa tilmaamaya in horumar dhab ah ay suurtagal tahay xitaa in lagu daaweeyo noocyada ugu khatarta badan ee kansarka, kuwaas oo aad u adag daawaynta jira.
War saxaafadeed lagu dhajiyay shabakada caafimaadka Xpress ayaa ka hadlaysa sifooyinka gaarka ah ee enzyme protein RIPK1. Isagu waa mid ka mid ah ka qaybgalayaasha habka necrosis unug. Si kastaba ha noqotee, sida saynisyahannadu ay ogaadeen, borotiinkani wuxuu sidoo kale xannibi karaa horumarinta neoplasms malignant iyo dhacdooyinka metastases. Natiijo ahaan, xaruntani waxay noqon kartaa mid ka mid ah qaybaha daawooyinka loogu talagalay daaweynta noocyada ugu khatarta badan ee kansarka.
Sida loo ogaaday natiijada daraasadda, RIPK1 waxay ka caawisaa in la yareeyo joogitaanka mitochondria ee unugyada. Kuwani waa xubnaha ka mas'uulka ah hirgelinta is-weydaarsiga tamarta. Marka lambarkoodu hoos u dhaco, waxa loogu yeero " stress ok" waxay bilaabataa inay horumarto. Qaddar aad u badan oo ah noocyada ogsijiinta fal-celiska ah waxay dhaawacdaa borotiinnada, DNA-da iyo lipids, taas oo ay sabab u tahay in habka is-burburinta unugu uu bilaabo. Si kale haddii loo dhigo, habka necrosis ama apoptosis unug ayaa la bilaabay.
Saynis yahanadu waxay xasuusinayaan in necrosis uu yahay geedi socodka bayoolajiga kaas oo unuga laftiisa la burburiyo, iyo sii deynta waxa ku jira waxay ku dhacdaa booska intercellular. Haddii unuggu u dhinto sida uu qabo barnaamijkiisa hidde-socodka, kaas oo loo yaqaan apoptosis, ka dibna hadhaagiisa ayaa laga saaraa nudaha, taas oo meesha ka saaraysa suurtogalnimada caabuqa.
Sida laga soo xigtay cilmi-baarayaasha Mareykanka, RIPK1 waxay noqon kartaa mid ka mid ah kicinta habka loo yaqaan " dhimashada unugyada la xakameeyey". Si kale haddii loo dhigo, waxaa loo isticmaali karaa hub ahaan "burburinta dhibicda" - si loogu dabaqo "ku-dhufashada" bartilmaameedka ah ee buro leh enzyme borotiin ah. Tani waxay kaa caawin doontaa joojinta habka metastasis iyo kordhinta neoplasm.